Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 Against Pediatric Acute Lymphoblastic Leukemia Xenografts

PURPOSE: Predictive biomarkers are required to identify patients who may benefit from the use of BH3 mimetics such as ABT-263. This study investigated the efficacy of ABT-263 against a panel of patient-derived pediatric acute lymphoblastic leukemia (ALL) xenografts and utilized cell and molecular ap...

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Main Authors: Suryani, Santi, Carol, Hernan, Chonghaile, Triona Ni, Frismantas, Viktoras, Sarmah, Chintanu, High, Laura, Bornhauser, Beat, Cowley, Mark J, Szymanska, Barbara, Evans, Kathryn, Boehm, Ingrid, Tonna, Elise, Jones, Luke, Manesh, Donya Moradi, Kurmasheva, Raushan T., Billups, Catherine, Kaplan, Warren, Letai, Anthony, Bourquin, Jean-Pierre, Houghton, Peter J, Smith, Malcolm A, Lock, Richard B
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154988/
https://ncbi.nlm.nih.gov/pubmed/25013123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0259
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