Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199

Human embryonic stem cells (hESCs) are hypersensitive to genotoxic stress and display lower survival ability relative to their differentiated progeny. Herein, we attempted to investigate the source of this difference by comparing the DNA damage responses triggered by the topoisomerase I inhibitor ca...

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Veröffentlicht in:PLoS One
Hauptverfasser: García, Carolina Paola, Videla Richardson, Guillermo Agustín, Dimopoulos, Nicolás Alexis, Fernandez Espinosa, Damián Darío, Miriuka, Santiago Gabriel, Sevlever, Gustavo Emilio, Romorini, Leonardo, Scassa, María Elida
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816327/
https://ncbi.nlm.nih.gov/pubmed/27030982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152607
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