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ABT-199 inhibits Hedgehog pathway by acting as a competitive inhibitor of oxysterol, rather as a BH3 mimetic

Aberrantly activated Hedgehog (Hh) pathway is critical for driving the initiation and progression of multiple types of cancers, including medulloblastoma (MB) and basal cellular carcinoma (BCC). The majority of current Hh antagonist function by targeting the transmembrane domain of the oncoprotein S...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Acta Pharmacol Sin
Hauptverfasser: Wang, Juan, Zhang, Yu, Huang, Wen-jing, Yang, Jun, Tang, Wei-guo, Huang, Tao-min, Tan, Wen-fu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Singapore 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149392/
https://ncbi.nlm.nih.gov/pubmed/32855528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-020-00504-4
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