Epigenetic states of cells of origin and tumor evolution drive tumor initiating cell phenotype and tumor heterogeneity

A central confounding factor in the development of targeted therapies is tumor cell heterogeneity, including as it occurs in tumor-initiating cells (TIC) within clinically identical tumors. Here we show how activation of the Sonic Hedgehog (SHH) pathway in neural stem and progenitor cells creates a...

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Autores principales: Chow, Kin-Hoe, Shin, Dong-Mi, Jenkins, Molly H., Miller, Emily E., Shih, David J., Choi, Seungbum, Low, Benjamin E., Philip, Vivek, Rybinski, Brad, Bronson, Roderick T., Taylor, Michael D., Yun, Kyuson
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154983/
https://ncbi.nlm.nih.gov/pubmed/25136069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3293
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