טוען...
Epigenetic states of cells of origin and tumor evolution drive tumor initiating cell phenotype and tumor heterogeneity
A central confounding factor in the development of targeted therapies is tumor cell heterogeneity, including as it occurs in tumor-initiating cells (TIC) within clinically identical tumors. Here we show how activation of the Sonic Hedgehog (SHH) pathway in neural stem and progenitor cells creates a...
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| Main Authors: | , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2014
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4154983/ https://ncbi.nlm.nih.gov/pubmed/25136069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-3293 |
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