STEM-18. DISTINCT BUT PREDICTABLE MECHANISMS DRIVE GENETIC VS. EPIGENETIC RESISTANCE TO TARGETED THERAPY

Emergence of therapy resistance greatly reduces long-term utility of effective targeted therapies, including SMO/SHH pathway inhibitors. SHH signaling is activated in ~25% of human medulloblastomas (MB) and FDA approved SMOi (to treat basal cell carcinoma (BCC)) are currently in clinical trials for...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: George, Joshy, Chen, Yaohui, Abdelfattah, Nourhan, Yamamoto, Keiko, Adamson, Scott, Rybinski, Bradley, Baskin, David, Chuang, Jeffrey, Yun, Kyuson
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847106/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.991
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge