STEM-18. DISTINCT BUT PREDICTABLE MECHANISMS DRIVE GENETIC VS. EPIGENETIC RESISTANCE TO TARGETED THERAPY

Emergence of therapy resistance greatly reduces long-term utility of effective targeted therapies, including SMO/SHH pathway inhibitors. SHH signaling is activated in ~25% of human medulloblastomas (MB) and FDA approved SMOi (to treat basal cell carcinoma (BCC)) are currently in clinical trials for...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: George, Joshy, Chen, Yaohui, Abdelfattah, Nourhan, Yamamoto, Keiko, Adamson, Scott, Rybinski, Bradley, Baskin, David, Chuang, Jeffrey, Yun, Kyuson
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847106/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.991
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