Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission

Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate Serine/Arginine-rich (SR) proteins involved in pre-mRNA processing. Four CLKs, termed PfCLK-1-4, can be identified in the human malaria parasite Plasmodium falciparum, which show homology with the yea...

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Detalhes bibliográficos
Main Authors: Kern, Selina, Agarwal, Shruti, Huber, Kilian, Gehring, André P., Strödke, Benjamin, Wirth, Christine C., Brügl, Thomas, Abodo, Liliane Onambele, Dandekar, Thomas, Doerig, Christian, Fischer, Rainer, Tobin, Andrew B., Alam, Mahmood M., Bracher, Franz, Pradel, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154858/
https://ncbi.nlm.nih.gov/pubmed/25188378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105732
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