Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications

An engineered anti-carcinoembryonic antigen (CEA) diabody (scFv dimer, 55 kDa) was previously constructed from the murine anti-CEA T84.66 antibody. Tumor targeting, imaging and biodistribution studies in nude mice bearing LS174T xenografts with radiolabeled anti-CEA diabody demonstrated rapid tumor...

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Detalhes bibliográficos
Main Authors: Olafsen, Tove, Cheung, Chia-wei, Yazaki, Paul J., Li, Lin, Sundaresan, Gobalakrishnan, Gambhir, Sanjiv S., Sherman, Mark A., Williams, Lawrence E., Shively, John E., Raubitschek, Andrew A., Wu, Anna M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154813/
https://ncbi.nlm.nih.gov/pubmed/14985534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzh009
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