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Site-specific, Thiol-mediated Conjugation of Fluorescent Probes to Cysteine-modified Diabodies Targeting CD20 or HER2
Small, engineered antibody fragments such as diabodies (50 kDa non-covalent dimers of single-chain Fv fragments) are useful alternatives to their larger antibody counterparts. However, due to their size, they are more susceptible to disruption of their antigen binding sites when modified using rando...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2668938/ https://ncbi.nlm.nih.gov/pubmed/19053310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc800113v |
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