Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation

Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma. MMSET catalyzes dimethylation of lysine 36 on histone H3 (H3K36me2), and its overexpression causes a global increase in H3K...

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Autors principals: Popovic, Relja, Martinez-Garcia, Eva, Giannopoulou, Eugenia G., Zhang, Quanwei, Zhang, Qingyang, Ezponda, Teresa, Shah, Mrinal Y., Zheng, Yupeng, Will, Christine M., Small, Eliza C., Hua, Youjia, Bulic, Marinka, Jiang, Yanwen, Carrara, Matteo, Calogero, Raffaele A., Kath, William L., Kelleher, Neil L., Wang, Ji-Ping, Elemento, Olivier, Licht, Jonathan D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4154646/
https://ncbi.nlm.nih.gov/pubmed/25188243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004566
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