Conantokins Derived from the Asprella Clade Impart ConRl-B, an NMDA Receptor Antagonist with a Unique Selectivity Profile for NR2B Subunits

Using molecular phylogeny has accelerated the discovery of peptidic ligands targeted to ion channels and receptors. One clade of venomous cone snails, Asprella, appears to be significantly enriched in conantokins, antagonists of N-Methyl D-Asparate receptors (NMDARs). Here, we describe the character...

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Main Authors: Gowd, Konkallu Hanumae, Han, Tiffany S., Twede, Vernon, Gajewiak, Joanna, Smith, Misty D., Watkins, Maren, Platt, Randall J., Toledo, Gabriela, White, H. Steve, Olivera, Baldomero M., Bulaj, Grzegorz
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153739/
https://ncbi.nlm.nih.gov/pubmed/22594498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300055n
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