Conantokins Derived from the Asprella Clade Impart ConRl-B, an NMDA Receptor Antagonist with a Unique Selectivity Profile for NR2B Subunits

Using molecular phylogeny has accelerated the discovery of peptidic ligands targeted to ion channels and receptors. One clade of venomous cone snails, Asprella, appears to be significantly enriched in conantokins, antagonists of N-Methyl D-Asparate receptors (NMDARs). Here, we describe the character...

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Auteurs principaux: Gowd, Konkallu Hanumae, Han, Tiffany S., Twede, Vernon, Gajewiak, Joanna, Smith, Misty D., Watkins, Maren, Platt, Randall J., Toledo, Gabriela, White, H. Steve, Olivera, Baldomero M., Bulaj, Grzegorz
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153739/
https://ncbi.nlm.nih.gov/pubmed/22594498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300055n
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