Stapling Mimics Noncovalent Interactions of γ-Carboxyglutamates in Conantokins, Peptidic Antagonists of N-Methyl-d-Aspartic Acid Receptors

Conantokins are short peptides derived from the venoms of marine cone snails that act as antagonists of the N-methyl-d-aspartate (NMDA) receptor family of excitatory glutamate receptors. These peptides contain γ-carboxyglutamic acid residues typically spaced at i,i+4 and/or i,i+7 intervals, which by...

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Hlavní autoři: Platt, Randall J., Han, Tiffany S., Green, Brad R., Smith, Misty D., Skalicky, Jack, Gruszczyński, Paweł, White, H. Steve, Olivera, Baldomero, Bulaj, Grzegorz, Gajewiak, Joanna
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370255/
https://ncbi.nlm.nih.gov/pubmed/22518838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350462
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