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Site-Specific Effects of Diselenide Bridges on the Oxidative Folding of a Cystine Knot Peptide, ω-Selenoconotoxin GVIA

Structural and functional studies of small, disulfide-rich peptides depend on their efficient chemical synthesis and folding. A large group of peptides derived from animals and plants contains the Cys pattern: C—C—CC—C—C that forms the inhibitory cystine knot (ICK) or knottin motif. Here we report t...

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書誌詳細
主要な著者: Gowd, Konkallu Hanumae, Yarotskyy, Viktor, Elmslie, Keith S., Skalicky, Jack J., Olivera, Baldomero M., Bulaj, Grzegorz
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867246/
https://ncbi.nlm.nih.gov/pubmed/20175537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi902137c
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