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A Pentasymmetric Open Channel Blocker for Cys-Loop Receptor Channels

γ-Aminobutyric acid type A receptors (GABA(A) receptors) are chloride ion channels composed of five subunits, mediating fast synaptic and tonic inhibition in the mammalian brain. These receptors show near five-fold symmetry that is most pronounced in the second trans-membrane domain M2 lining the Cl...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Carta, Valentina, Pangerl, Michael, Baur, Roland, Puthenkalam, Roshan, Ernst, Margot, Trauner, Dirk, Sigel, Erwin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153658/
https://ncbi.nlm.nih.gov/pubmed/25184303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106688
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