Loop diuretics are open-channel blockers of the cystic fibrosis transmembrane conductance regulator with distinct kinetics

BACKGROUND AND PURPOSE: Loop diuretics are widely used to inhibit the Na(+), K(+), 2Cl(−) co-transporter, but they also inhibit the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel. Here, we investigated the mechanism of CFTR inhibition by loop diuretics and explored the effe...

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Detalhes bibliográficos
Main Authors: Ju, Min, Scott-Ward, Toby S, Liu, Jia, Khuituan, Pissared, Li, Hongyu, Cai, Zhiwei, Husbands, Stephen M, Sheppard, David N
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874712/
https://ncbi.nlm.nih.gov/pubmed/24117047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12458
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