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A Numerical Method for Analysis of In Vitro Time-Dependent Inhibition Data. Part 2. Application to Experimental Data
Time-dependent inhibition (TDI) of cytochrome P450 enzymes is an important cause of drug-drug interactions. The standard approach to characterize the kinetics of TDI is to determine the rate of enzyme loss, k(obs), at various inhibitor concentrations, [I], and replot the k(obs) versus [I] to obtain...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4152872/ https://ncbi.nlm.nih.gov/pubmed/24939653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.058297 |
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