The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein

BACKGROUND: Regions within solid tumours often experience oxygen deprivation, which is associated with resistance to chemotherapy and irradiation. The aim of this study was to evaluate the radiosensitising effect of gemcitabine and its main metabolite dFdU under normoxia versus hypoxia and to determ...

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Detalhes bibliográficos
Main Authors: Wouters, An, Pauwels, Bea, Burrows, Natalie, Baay, Marc, Deschoolmeester, Vanessa, Vu, Trung Nghia, Laukens, Kris, Meijnders, Paul, Van Gestel, Dirk, Williams, Kaye J, Van den Weyngaert, Danielle, Vermorken, Jan B, Pauwels, Patrick, Peeters, Marc, Lardon, Filip
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4152599/
https://ncbi.nlm.nih.gov/pubmed/25128202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-594
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