In vitro study on the schedule-dependency of the interaction between pemetrexed, gemcitabine and irradiation in non-small cell lung cancer and head and neck cancer cells

BACKGROUND: Based on their different mechanisms of action, non-overlapping side effects and radiosensitising potential, combining the antimetabolites pemetrexed (multitargeted antifolate, MTA) and gemcitabine (2',2'-difluorodeoxycytidine, dFdC) with irradiation (RT) seems promising. This i...

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Autori principali: Wouters, An, Pauwels, Bea, Lardon, Filip, Pattyn, Greet GO, Lambrechts, Hilde AJ, Baay, Marc, Meijnders, Paul, Vermorken, Jan B
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2931492/
https://ncbi.nlm.nih.gov/pubmed/20723210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-441
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