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Role of Metalation in the Topoisomerase IIα Inhibition and Antiproliferation Activity of a Series of α-Heterocyclic-N(4)-Substituted Thiosemicarbazones and Their Cu(II) Complexes
[Image: see text] The topoisomerase-IIα inhibition and antiproliferative activity of α-heterocyclic thiosemicarbazones and their corresponding copper(II) complexes have been investigated. The Cu(II)(thiosemicarbazonato)Cl complexes were shown to catalytically inhibit topoisomerase-IIα at concentrati...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151564/ https://ncbi.nlm.nih.gov/pubmed/21391686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101532u |
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