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Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones
Triapine is an α-N-heterocyclic thiosemicarbazone with promising anticancer activity against hematologic malignancies but widely ineffective against solid tumor types in clinical trials. The anticancer activity of thiosemicarbazones can be dramatically increased by terminal dimethylation. KP1089 is...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Elsevier Science
2012
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3342514/ https://ncbi.nlm.nih.gov/pubmed/22426010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.03.004 |
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