Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

Triapine is an α-N-heterocyclic thiosemicarbazone with promising anticancer activity against hematologic malignancies but widely ineffective against solid tumor types in clinical trials. The anticancer activity of thiosemicarbazones can be dramatically increased by terminal dimethylation. KP1089 is...

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Main Authors: Heffeter, Petra, Pirker, Christine, Kowol, Christian R., Herrman, Gerrit, Dornetshuber, Rita, Miklos, Walter, Jungwirth, Ute, Koellensperger, Gunda, Keppler, Bernhard K., Berger, Walter
格式: Artigo
語言:Inglês
出版: Elsevier Science 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342514/
https://ncbi.nlm.nih.gov/pubmed/22426010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.03.004
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