Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling

Triapine, an anticancer thiosemicarbazone, is currently under clinical investigation. Whereas promising results were obtained in hematological diseases, trials in solid tumors widely failed. To understand mechanisms causing triapine insensitivity, we have analysed genomic alterations in a triapine-r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Miklos, Walter, Heffeter, Petra, Pirker, Christine, Hager, Sonja, Kowol, Christian R., van Schoonhoven, Sushilla, Stojanovic, Mirjana, Keppler, Bernhard K., Berger, Walter
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2016
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356681/
https://ncbi.nlm.nih.gov/pubmed/27602951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11821
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