Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling

Triapine, an anticancer thiosemicarbazone, is currently under clinical investigation. Whereas promising results were obtained in hematological diseases, trials in solid tumors widely failed. To understand mechanisms causing triapine insensitivity, we have analysed genomic alterations in a triapine-r...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Miklos, Walter, Heffeter, Petra, Pirker, Christine, Hager, Sonja, Kowol, Christian R., van Schoonhoven, Sushilla, Stojanovic, Mirjana, Keppler, Bernhard K., Berger, Walter
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356681/
https://ncbi.nlm.nih.gov/pubmed/27602951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11821
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