Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling

Triapine, an anticancer thiosemicarbazone, is currently under clinical investigation. Whereas promising results were obtained in hematological diseases, trials in solid tumors widely failed. To understand mechanisms causing triapine insensitivity, we have analysed genomic alterations in a triapine-r...

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Publicado en:Oncotarget
Autores principales: Miklos, Walter, Heffeter, Petra, Pirker, Christine, Hager, Sonja, Kowol, Christian R., van Schoonhoven, Sushilla, Stojanovic, Mirjana, Keppler, Bernhard K., Berger, Walter
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356681/
https://ncbi.nlm.nih.gov/pubmed/27602951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11821
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