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Does PTEN Loss Impair DNA Double-Strand Break Repair by Homologous Recombination?

The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and...

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Sonraí Bibleagrafaíochta
Main Authors: Hunt, Clayton R., Gupta, Arun, Horikoshi, Nobuo, Pandita, Tej K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151559/
https://ncbi.nlm.nih.gov/pubmed/22179663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-3131
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