Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth and Metastasis

PURPOSE: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of phosphoinositide 3-kinase (PI3K) pathway. We intend to use a novel anti-GRP78m...

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Détails bibliographiques
Auteurs principaux: Liu, Ren, Li, Xiuqing, Gao, Wenming, Zhou, Yue, Wey, Shiuan, Mitra, Satyajit, Krasnoperov, Valery, Dong, Dezheng, Liu, Shuanglong, Li, Dan, Zhu, Genyuan, Louie, Stan, Conti, Peter S., Li, Zibo, Lee, Amy S., Gill, Parkash S.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151476/
https://ncbi.nlm.nih.gov/pubmed/24048331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-1106
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