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DNA Ligase IV regulates XRCC4 nuclear localization

DNA Ligase IV, along with its interacting partner XRCC4, are essential for repairing DNA double strand breaks by non-homologous end joining (NHEJ). Together, they complete the final ligation step resolving the DNA break. Ligase IV is regulated by XRCC4 and XLF. However, the mechanism(s) by which Lig...

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Hlavní autoři: Francis, Dailia B., Kozlov, Mikhail, Chavez, Jose, Chu, Jennifer, Malu, Shruti, Hanna, Mary, Cortes, Patricia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151352/
https://ncbi.nlm.nih.gov/pubmed/24984242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.05.010
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