Proteasome function is required for platelet production

The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet production. Here we determined that pharmacologic inhibition of proteas...

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Bibliografiset tiedot
Päätekijät: Shi, Dallas S., Smith, Matthew C.P., Campbell, Robert A., Zimmerman, Patrick W., Franks, Zechariah B., Kraemer, Bjorn F., Machlus, Kellie R., Ling, Jing, Kamba, Patrick, Schwertz, Hansjörg, Rowley, Jesse W., Miles, Rodney R., Liu, Zhi-Jian, Sola-Visner, Martha, Italiano, Joseph E., Christensen, Hilary, Kahr, Walter H.A., Li, Dean Y., Weyrich, Andrew S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151230/
https://ncbi.nlm.nih.gov/pubmed/25061876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75247
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