Proteasome function is required for platelet production

The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet production. Here we determined that pharmacologic inhibition of proteas...

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Main Authors: Shi, Dallas S., Smith, Matthew C.P., Campbell, Robert A., Zimmerman, Patrick W., Franks, Zechariah B., Kraemer, Bjorn F., Machlus, Kellie R., Ling, Jing, Kamba, Patrick, Schwertz, Hansjörg, Rowley, Jesse W., Miles, Rodney R., Liu, Zhi-Jian, Sola-Visner, Martha, Italiano, Joseph E., Christensen, Hilary, Kahr, Walter H.A., Li, Dean Y., Weyrich, Andrew S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151230/
https://ncbi.nlm.nih.gov/pubmed/25061876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75247
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