Proteasome function is required for platelet production

The proteasome inhibiter bortezomib has been successfully used to treat patients with relapsed multiple myeloma; however, many of these patients become thrombocytopenic, and it is not clear how the proteasome influences platelet production. Here we determined that pharmacologic inhibition of proteas...

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Hauptverfasser: Shi, Dallas S., Smith, Matthew C.P., Campbell, Robert A., Zimmerman, Patrick W., Franks, Zechariah B., Kraemer, Bjorn F., Machlus, Kellie R., Ling, Jing, Kamba, Patrick, Schwertz, Hansjörg, Rowley, Jesse W., Miles, Rodney R., Liu, Zhi-Jian, Sola-Visner, Martha, Italiano, Joseph E., Christensen, Hilary, Kahr, Walter H.A., Li, Dean Y., Weyrich, Andrew S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151230/
https://ncbi.nlm.nih.gov/pubmed/25061876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75247
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