Novel Anti-bacterial Activities of β-defensin 1 in Human Platelets: Suppression of Pathogen Growth and Signaling of Neutrophil Extracellular Trap Formation

Human β-defensins (hBD) are antimicrobial peptides that curb microbial activity. Although hBD's are primarily expressed by epithelial cells, we show that human platelets express hBD-1 that has both predicted and novel antibacterial activities. We observed that activated platelets surround Staph...

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Detalhes bibliográficos
Main Authors: Kraemer, Bjoern F., Campbell, Robert A., Schwertz, Hansjörg, Cody, Mark J., Franks, Zechariah, Tolley, Neal D., Kahr, Walter H. A., Lindemann, Stephan, Seizer, Peter, Yost, Christian C., Zimmerman, Guy A., Weyrich, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213094/
https://ncbi.nlm.nih.gov/pubmed/22102811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002355
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