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Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
To minimize oxidative damage to the cell, malfunctioning mitochondria need to be removed by mitophagy. In neuronal axons, mitochondrial damage may occur in distal regions, far from the soma where most lysosomal degradation is thought to occur. In this paper, we report that PINK1 and Parkin, two Park...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4151150/ https://ncbi.nlm.nih.gov/pubmed/25154397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201401070 |
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