Cis-acting DNA sequence at a replication origin promotes repeat expansion to fragile X full mutation

Fragile X syndrome (FXS) is caused by CGG repeat expansion that leads to FMR1 silencing. Women with a premutation allele are at risk of having a full mutation child with FXS. To investigate the mechanism of repeat expansion, we examined the relationship between a single-nucleotide polymorphism (SNP)...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Gerhardt, Jeannine, Zaninovic, Nikica, Zhan, Qiansheng, Madireddy, Advaitha, Nolin, Sarah L., Ersalesi, Nicole, Yan, Zi, Rosenwaks, Zev, Schildkraut, Carl L.
פורמט: Artigo
שפה:Inglês
יצא לאור: The Rockefeller University Press 2014
נושאים:
Research Articles
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151148/
https://ncbi.nlm.nih.gov/pubmed/25179629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201404157
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים