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The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells
Fragile X syndrome (FXS) is caused by a CGG repeat expansion in the FMR1 gene that appears to occur during oogenesis and during early embryogenesis. One model proposes that repeat instability depends on the replication fork direction through the repeats such that (CNG)(n) hairpin-like structures for...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3920742/ https://ncbi.nlm.nih.gov/pubmed/24289922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.029 |
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