The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells

Fragile X syndrome (FXS) is caused by a CGG repeat expansion in the FMR1 gene that appears to occur during oogenesis and during early embryogenesis. One model proposes that repeat instability depends on the replication fork direction through the repeats such that (CNG)(n) hairpin-like structures for...

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Main Authors: Gerhardt, Jeannine, Tomishima, Mark J., Zaninovic, Nikica, Colak, Dilek, Yan, Zi, Zhan, Qiansheng, Rosenwaks, Zev, Jaffrey, Samie R., Schildkraut, Carl L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920742/
https://ncbi.nlm.nih.gov/pubmed/24289922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.029
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