The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells

Fragile X syndrome (FXS) is caused by a CGG repeat expansion in the FMR1 gene that appears to occur during oogenesis and during early embryogenesis. One model proposes that repeat instability depends on the replication fork direction through the repeats such that (CNG)(n) hairpin-like structures for...

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Главные авторы: Gerhardt, Jeannine, Tomishima, Mark J., Zaninovic, Nikica, Colak, Dilek, Yan, Zi, Zhan, Qiansheng, Rosenwaks, Zev, Jaffrey, Samie R., Schildkraut, Carl L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920742/
https://ncbi.nlm.nih.gov/pubmed/24289922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.10.029
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