Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

Epigenetic gene silencing is seen in several repeat-expansion diseases. In fragile X syndrome, the most common genetic form of mental retardation, a CGG trinucleotide–repeat expansion adjacent to the fragile X mental retardation 1 (FMR1) gene promoter results in its epigenetic silencing. Here, we sh...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Science
Main Authors: Colak, Dilek, Zaninovic, Nikica, Cohen, Michael S., Rosenwaks, Zev, Yang, Wang-Yong, Gerhardt, Jeannine, Disney, Matthew D., Jaffrey, Samie R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357282/
https://ncbi.nlm.nih.gov/pubmed/24578575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1245831
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados