Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome

Epigenetic gene silencing is seen in several repeat-expansion diseases. In fragile X syndrome, the most common genetic form of mental retardation, a CGG trinucleotide–repeat expansion adjacent to the fragile X mental retardation 1 (FMR1) gene promoter results in its epigenetic silencing. Here, we sh...

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Détails bibliographiques
Publié dans:Science
Auteurs principaux: Colak, Dilek, Zaninovic, Nikica, Cohen, Michael S., Rosenwaks, Zev, Yang, Wang-Yong, Gerhardt, Jeannine, Disney, Matthew D., Jaffrey, Samie R.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357282/
https://ncbi.nlm.nih.gov/pubmed/24578575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1245831
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