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Concise Chemoenzymatic Three-Step Total Synthesis of Isosolenopsin through Medium Engineering

A short and efficient total synthesis of the alkaloid isosolenopsin and its enantiomer has been achieved. The key step was a ω-transaminase-catalysed regioselective monoamination of the diketone pentadecane-2,6-dione, which was obtained in a single step through the application of a Grignard reaction...

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Detalhes bibliográficos
Main Authors: Simon, Robert C, Fuchs, Christine S, Lechner, Horst, Zepeck, Ferdinand, Kroutil, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151137/
https://ncbi.nlm.nih.gov/pubmed/25191103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejoc.201300157
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