Platelets Promote Mitochondrial Uncoupling and Resistance to Apoptosis in Leukemia Cells: A Novel Paradigm for the Bone Marrow Microenvironment

Here we report that leukemia cell lines and primary CD34+ leukemic blasts exposed to platelet rich plasma (PRP) or platelet lysates (PL) display increased resistance to apoptosis induced by mitochondria-targeted agents ABT-737 and CDDO-Me. Intriguingly, leukemia cells exposed to platelet components...

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Detalhes bibliográficos
Main Authors: Velez, Juliana, Enciso, Leonardo José, Suarez, Marta, Fiegl, Michael, Grismaldo, Adriana, López, Catalina, Barreto, Alfonso, Cardozo, Claudia, Palacios, Pilar, Morales, Ludis, Duque, Jorge Eduardo, Carmona, Jorge Uriel, Konopleva, Marina, Andreeff, Michael, Samudio, Ismael
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2014
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150878/
https://ncbi.nlm.nih.gov/pubmed/25112275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12307-014-0149-3
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