Platelets Promote Mitochondrial Uncoupling and Resistance to Apoptosis in Leukemia Cells: A Novel Paradigm for the Bone Marrow Microenvironment

Here we report that leukemia cell lines and primary CD34+ leukemic blasts exposed to platelet rich plasma (PRP) or platelet lysates (PL) display increased resistance to apoptosis induced by mitochondria-targeted agents ABT-737 and CDDO-Me. Intriguingly, leukemia cells exposed to platelet components...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Velez, Juliana, Enciso, Leonardo José, Suarez, Marta, Fiegl, Michael, Grismaldo, Adriana, López, Catalina, Barreto, Alfonso, Cardozo, Claudia, Palacios, Pilar, Morales, Ludis, Duque, Jorge Eduardo, Carmona, Jorge Uriel, Konopleva, Marina, Andreeff, Michael, Samudio, Ismael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2014
Schlagworte:
Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150878/
https://ncbi.nlm.nih.gov/pubmed/25112275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12307-014-0149-3
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge