Platelets Promote Mitochondrial Uncoupling and Resistance to Apoptosis in Leukemia Cells: A Novel Paradigm for the Bone Marrow Microenvironment

Here we report that leukemia cell lines and primary CD34+ leukemic blasts exposed to platelet rich plasma (PRP) or platelet lysates (PL) display increased resistance to apoptosis induced by mitochondria-targeted agents ABT-737 and CDDO-Me. Intriguingly, leukemia cells exposed to platelet components...

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Autori principali: Velez, Juliana, Enciso, Leonardo José, Suarez, Marta, Fiegl, Michael, Grismaldo, Adriana, López, Catalina, Barreto, Alfonso, Cardozo, Claudia, Palacios, Pilar, Morales, Ludis, Duque, Jorge Eduardo, Carmona, Jorge Uriel, Konopleva, Marina, Andreeff, Michael, Samudio, Ismael
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2014
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150878/
https://ncbi.nlm.nih.gov/pubmed/25112275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12307-014-0149-3
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