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Chimeric bifunctional oligonucleotides as a novel tool to invade telomerase assembly

Telomerase is a key participant in the telomere length maintaining system in eukaryotic cells. Telomerase RNA and protein reverse transcriptase subunits are essential for the appearance of active telomerase in vitro. Telomerase is active in many cancer types and is a potential target for anticancer...

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Hlavní autoři: Azhibek, Dulat, Zvereva, Maria, Zatsepin, Timofei, Rubtsova, Maria, Dontsova, Olga
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150790/
https://ncbi.nlm.nih.gov/pubmed/25081209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku688
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