Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase

The elongation of single-stranded DNA repeats at the 3′-ends of chromosomes by telomerase is a key process in maintaining genome integrity in eukaryotes. Abnormal activation of telomerase leads to uncontrolled cell division, whereas its down-regulation is attributed to ageing and several pathologies...

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發表在:Nucleic Acids Res
Main Authors: Petrova, Olga A, Mantsyzov, Alexey B, Rodina, Elena V, Efimov, Sergey V, Hackenberg, Claudia, Hakanpää, Johanna, Klochkov, Vladimir V, Lebedev, Andrej A, Chugunova, Anastasia A, Malyavko, Alexander N, Zatsepin, Timofei S, Mishin, Alexey V, Zvereva, Maria I, Lamzin, Victor S, Dontsova, Olga A, Polshakov, Vladimir I
格式: Artigo
語言:Inglês
出版: Oxford University Press 2018
主題:
Structural Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814841/
https://ncbi.nlm.nih.gov/pubmed/29294091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1275
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