Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase

The elongation of single-stranded DNA repeats at the 3′-ends of chromosomes by telomerase is a key process in maintaining genome integrity in eukaryotes. Abnormal activation of telomerase leads to uncontrolled cell division, whereas its down-regulation is attributed to ageing and several pathologies...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Petrova, Olga A, Mantsyzov, Alexey B, Rodina, Elena V, Efimov, Sergey V, Hackenberg, Claudia, Hakanpää, Johanna, Klochkov, Vladimir V, Lebedev, Andrej A, Chugunova, Anastasia A, Malyavko, Alexander N, Zatsepin, Timofei S, Mishin, Alexey V, Zvereva, Maria I, Lamzin, Victor S, Dontsova, Olga A, Polshakov, Vladimir I
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Structural Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5814841/
https://ncbi.nlm.nih.gov/pubmed/29294091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx1275
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