PARP1 Regulates the Biogenesis and Activity of Telomerase Complex Through Modification of H/ACA-Proteins

Poly(ADP-ribose) polymerase 1 (PARP1) is established as a key regulator of the cellular DNA damage response and apoptosis. In addition, PARP1 participates in the global regulation of DNA repair, transcription, telomere maintenance, and inflammation response by modulating various DNA-protein and prot...

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Bibliographic Details
Published in:Front Cell Dev Biol
Main Authors: Savelyev, Nikita V., Shepelev, Nikita M., Lavrik, Olga I., Rubtsova, Maria P., Dontsova, Olga A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170401/
https://ncbi.nlm.nih.gov/pubmed/34095104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.621134
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