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Imputation Without Doing Imputation: A New Method for the Detection of Non-Genotyped Causal Variants

Genome-wide association studies allow detection of non-genotyped disease-causing variants through testing of nearby genotyped SNPs. This approach may fail when there are no genotyped SNPs in strong LD with the causal variant. Several genotyped SNPs in weak LD with the causal variant may, however, co...

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Detalhes bibliográficos
Main Authors: Howey, Richard, Cordell, Heather J
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4150535/
https://ncbi.nlm.nih.gov/pubmed/24535679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.21792
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