A New Genotype Imputation Method with Tolerance to High Missing Rate and Rare Variants

We report a novel algorithm, iBLUP, to impute missing genotypes by simultaneously and comprehensively using identity by descent and linkage disequilibrium information. The simulation studies showed that the algorithm exhibited drastically tolerance to high missing rate, especially for rare variants...

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Autors principals: Yang, Yumei, Wang, Qishan, Chen, Qiang, Liao, Rongrong, Zhang, Xiangzhe, Yang, Hongjie, Zheng, Youmin, Zhang, Zhiwu, Pan, Yuchun
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074155/
https://ncbi.nlm.nih.gov/pubmed/24972110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101025
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