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A New Genotype Imputation Method with Tolerance to High Missing Rate and Rare Variants
We report a novel algorithm, iBLUP, to impute missing genotypes by simultaneously and comprehensively using identity by descent and linkage disequilibrium information. The simulation studies showed that the algorithm exhibited drastically tolerance to high missing rate, especially for rare variants...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4074155/ https://ncbi.nlm.nih.gov/pubmed/24972110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101025 |
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