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A New Genotype Imputation Method with Tolerance to High Missing Rate and Rare Variants

We report a novel algorithm, iBLUP, to impute missing genotypes by simultaneously and comprehensively using identity by descent and linkage disequilibrium information. The simulation studies showed that the algorithm exhibited drastically tolerance to high missing rate, especially for rare variants...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Yang, Yumei, Wang, Qishan, Chen, Qiang, Liao, Rongrong, Zhang, Xiangzhe, Yang, Hongjie, Zheng, Youmin, Zhang, Zhiwu, Pan, Yuchun
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2014
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4074155/
https://ncbi.nlm.nih.gov/pubmed/24972110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101025
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