Epigenetic landscape during osteoblastogenesis defines a differentiation-dependent Runx2 promoter region

Runx2 is a developmentally regulated gene in vertebrates and is essential for bone formation and skeletal homeostasis. The induction of runx2-P1 isoform transcripts is a hallmark of early osteoblastogenesis. Although previous in vitro studies have defined a minimal Runx2-P1 promoter sequence with we...

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Autori principali: Tai, Phillip W. L., Wu, Hai, Gordon, Jonathan A. R., Whitfield, Troy W., Barutcu, A. Rasim, van Wijnen, André J., Lian, Jane B., Stein, Gary S., Stein, Janet L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149845/
https://ncbi.nlm.nih.gov/pubmed/24881813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2014.05.044
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