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Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters

An enigma in the field of peptide transport is the structural basis for ligand promiscuity, as exemplified by PepT1, the mammalian plasma membrane peptide transporter. Here, we present crystal structures of di- and tripeptide-bound complexes of a bacterial homologue of PepT1, which reveal at least t...

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書誌詳細
主要な著者: Lyons, Joseph A, Parker, Joanne L, Solcan, Nicolae, Brinth, Alette, Li, Dianfan, Shah, Syed TA, Caffrey, Martin, Newstead, Simon
フォーマット: Artigo
言語:Inglês
出版事項: BlackWell Publishing Ltd 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149780/
https://ncbi.nlm.nih.gov/pubmed/24916388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201338403
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