Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters

An enigma in the field of peptide transport is the structural basis for ligand promiscuity, as exemplified by PepT1, the mammalian plasma membrane peptide transporter. Here, we present crystal structures of di- and tripeptide-bound complexes of a bacterial homologue of PepT1, which reveal at least t...

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Hlavní autoři: Lyons, Joseph A, Parker, Joanne L, Solcan, Nicolae, Brinth, Alette, Li, Dianfan, Shah, Syed TA, Caffrey, Martin, Newstead, Simon
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4149780/
https://ncbi.nlm.nih.gov/pubmed/24916388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201338403
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