The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways

We have assessed whether viscoelastic gels known to inhibit mucociliary clearance can increase lipid-mediated gene transfer. Methylcellulose or carboxymethylcellulose (0.25 to 1.5%) were mixed with complexes of the cationic lipid GL67A and plasmids encoding luciferase and perfused onto the nasal epi...

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Detalhes bibliográficos
Main Authors: Griesenbach, Uta, Meng, Cuixiang, Farley, Raymond, Wasowicz, Marguerite, Munkonge, Felix M, Chan, Mario, Stoneham, Charlotte, Sumner-Jones, Stephanie, Pringle, Ian A., Gill, Deborah R., Hyde, Stephen C., Stevenson, Barbara, Holder, Emma, Ban, Hiroshi, Hasegawa, Mamoru, Cheng, Seng H, Scheule, Ronald K, Sinn, Patrick L, McCray, Paul B, Alton, Eric WFW
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148698/
https://ncbi.nlm.nih.gov/pubmed/20022367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2009.12.005
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