HIV-1 Expression Within Resting CD4(+) T Cells After Multiple Doses of Vorinostat

Background. A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-regulates HIV RNA expression within resting CD4(+) T cells of treated, aviremic human immunodeficiency virus (HIV)–positive participants. The ability of multiple exposures to VOR to repeatedly disrupt latency has not...

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Autori principali: Archin, Nancy M., Bateson, Rosalie, Tripathy, Manoj K., Crooks, Amanda M., Yang, Kuo-Hsiung, Dahl, Noelle P., Kearney, Mary F., Anderson, Elizabeth M., Coffin, John M., Strain, Matthew C., Richman, Douglas D., Robertson, Kevin R., Kashuba, Angela D., Bosch, Ronald J., Hazuda, Daria J., Kuruc, Joann D., Eron, Joseph J., Margolis, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148603/
https://ncbi.nlm.nih.gov/pubmed/24620025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu155
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