Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity

Identification of agents that target human leukemia stem cells (LSCs) is an important consideration for the development of new therapies. The present study demonstrates that rocaglamide and silvestrol, closely related natural products from the flavagline class of compounds, are able to preferentiall...

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Main Authors: Callahan, Kevin P., Minhajuddin, Mohammad, Corbett, Cheryl, Lagadinou, Eleni D., Rossi, Randall M., Grose, Valerie, Balys, Marlene M., Pan, Li, Jacob, Steven, Frontier, Alison, Grever, Michael R., Lucas, David M., Kinghorn, A. Douglas, Liesveld, Jane L., Becker, Michael W., Jordan, Craig T.
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148474/
https://ncbi.nlm.nih.gov/pubmed/24577530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.93
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